Russian Expert Warns of Health Risks from Manganese Deficiency and Excess

Dr. Andrey Skalny, a specialist at the Institute of Nutrition Research, emphasized that manganese often receives less attention compared to other widely recognized and commonly used nutrients.

He stated that manganese is a vital trace element, and both its deficiency and excess can lead to serious health complications.

Role of Manganese in Immune and Connective Tissue Health

Manganese influences the immune system as a component of an antioxidant enzyme that neutralizes superoxide radicals. This enzyme protects mitochondria and nerve cells from damage. Reduced activity of this enzyme increases oxidative stress, which may result in cancer and inflammatory conditions.

Additionally, manganese is essential for synthesizing glycosaminoglycans, including hyaluronic acid and chondroitin sulfate, which are involved in the normal functioning of connective tissues.

Consequences of Manganese Deficiency on Musculoskeletal and Reproductive Systems

Deficiency in manganese manifests in the musculoskeletal system as impaired growth and development, bone and cartilage problems, and delayed wound healing.

Alongside copper deficiency, low manganese levels reduce the activity of bone-forming cells and decrease bone mineralization. This can increase the risk of fractures, lower bone density, and lead to osteoporosis.

Dr. Skalny advised that women should pay particular attention to their manganese levels because manganese participates in the synthesis of sex hormones, especially progesterone and prolactin. A lack of progesterone can cause pelvic organ fibrosis and infertility in women. Manganese deficiency also adversely affects ovarian function and raises the risk of infertility.

Manganese’s Impact on Glucose Metabolism and Protein Processing

The expert pointed out that manganese activates enzymes involved in gluconeogenesis, the production of glucose from non-carbohydrate sources. These enzymes convert lactate and amino acids into glucose, maintaining adequate energy production in the body.

He explained, "Manganese deficiency weakens glucose utilization and may cause insulin resistance, a predisposing factor for diabetes. Studies have shown that manganese deficiency is common among individuals with type 2 diabetes, obesity, and metabolic syndrome."

Moreover, manganese is necessary for the normal function of an enzyme involved in protein metabolism. A deficiency reduces the liver’s ability to detoxify ammonia, contributing to toxicity.

Neurological Effects and Risks of Manganese Imbalance

Manganese also plays a role in nervous system functions, regulating emotions and cognitive processes. Its deficiency can lead to memory impairment, depression, and epilepsy.

Dr. Skalny warned, "However, it is important to know that excessive manganese in the human body causes neurological problems, reduces cognitive functions, and contributes to symptoms resembling Parkinson’s disease."